Drug DiscoveryPreprintPreprint

A Two-Phase Peripheral Drug Sequestration Strategy Using Protein Binders and Transient mRNA Expression to Reduce CNS Exposure to Fentanyl

Alkhaleeli, Rami 2025-12-24 58 views

Preprint notice: This work is a preprint and has not undergone external peer review. It should not be used to guide clinical practice. Findings are preliminary and subject to change.

Abstract

The ongoing opioid crisis continues to result in unacceptable overdose mortality. This work presents a conceptual two-phase peripheral drug sequestration framework designed to reduce central nervous system (CNS) exposure to fentanyl without interfering with opioid receptor signaling, based on engineered fentanyl-binding proteins.

Keywords

Addiction harm reduction fentanyl peripheral drug sequestration protein binders mRNA therapeutics overdose prevention blood-brain barrier medication-assisted treatment

Cite This Work

Recommended citation and downloadable formats.

Alkhaleeli, R. (2025). A Two-Phase Peripheral Drug Sequestration Strategy Using Protein Binders and Transient mRNA Expression to Reduce CNS Exposure to Fentanyl. Zenodo. https://doi.org/10.5281/zenodo.18041349

APA

Alkhaleeli, R. (2025). A Two-Phase Peripheral Drug Sequestration Strategy Using Protein Binders and Transient mRNA Expression to Reduce CNS Exposure to Fentanyl. Zenodo. https://doi.org/10.5281/zenodo.18041349

MLA

Alkhaleeli, Rami "A Two-Phase Peripheral Drug Sequestration Strategy Using Protein Binders and Transient mRNA Expression to Reduce CNS Exposure to Fentanyl." Zenodo, 2025-12-24, https://doi.org/10.5281/zenodo.18041349.

Chicago

Alkhaleeli, Rami. "A Two-Phase Peripheral Drug Sequestration Strategy Using Protein Binders and Transient mRNA Expression to Reduce CNS Exposure to Fentanyl." Zenodo. 2025-12-24. https://doi.org/10.5281/zenodo.18041349.

BibTeX

@misc{alkhaleeli_18041349,
  author       = {Alkhaleeli, Rami},
  title        = {A Two-Phase Peripheral Drug Sequestration Strategy Using Protein Binders and Transient mRNA Expression to Reduce CNS Exposure to Fentanyl},
  year         = {2025},
  publisher    = {Zenodo},
  doi          = {10.5281/zenodo.18041349},
  url          = {https://doi.org/10.5281/zenodo.18041349}
}

RIS

TY  - GEN
AU  - Alkhaleeli, Rami
PY  - 2025
TI  - A Two-Phase Peripheral Drug Sequestration Strategy Using Protein Binders and Transient mRNA Expression to Reduce CNS Exposure to Fentanyl
PB  - Zenodo
DO  - 10.5281/zenodo.18041349
UR  - https://doi.org/10.5281/zenodo.18041349
ER  -

A Two-Phase Peripheral Drug Sequestration Strategy Using Protein Binders and Transient mRNA Expression to Reduce CNS Exposure to Fentanyl

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Publication Details

DOI10.5281/zenodo.18041349

Publication TypePreprint

Research FieldDrug Discovery

Publication Date2025-12-24

Author(s)Alkhaleeli, Rami

LicenseCC-BY-4.0

AccessRestricted

SourceZenodo

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