Our Work — Computational Drug & mRNA Vaccine Research
Documented AI-assisted drug discovery and in-silico mRNA vaccine research examples — 16 research concepts by Alkhaleeli BioAI LLC.
mRNA Design Workflow
Computational design pipeline used across these research concepts — all steps are in-silico predictions and design concepts.
Biological Target
Disease & molecular target identification
Sequence Analysis
Sequence retrieval & epitope/domain mapping
Computational Optimization
Codon optimization, AI ranking & simulation
mRNA Design
Construct assembly & LNP formulation concept
Predicted Protein Expression
In-silico translation & expression prediction
Proposed Biological Response
Modeled immune/therapeutic response
These projects are scientific research designs and computational proof-of-concept studies. They are not approved medical products, experimentally validated cures, or guarantees of therapeutic effectiveness.
Featured Research — Free to Access
ALS — SOD1 Genetic Mutation & RNA Therapeutic Research
Our publicly shared ALS computational research is free to access. doi.org/10.5281/zenodo.23632865
AI-Guided Immune Programming & Personalized Cancer mRNA Vaccines
Adaptive immune design frameworks pairing synthetic-molecule immune programming with patient-specific neoantigen mRNA vaccine strategies.
Animal-Free LC-MS Endotoxin & Microbial Detection
A conceptual animal-free analytical workflow that differentiates endotoxin and microbial contamination by mass-spectrometric molecular fingerprints.
Hunter Syndrome — IDS mRNA Therapeutic Design
An AI-optimized mRNA construct concept designed to restore iduronate-2-sulfatase (IDS) expression in Hunter syndrome (MPS II).
Scientific diagram available inside the case study
Autoimmune Diseases — Antigen-Specific mRNA Immune Tolerance
A conceptual antigen-specific immune-tolerance strategy exploring mRNA-encoded self-antigens to retrain autoreactive immune responses.
Ebola — Multi-Epitope mRNA Vaccine Candidate
A computational multi-epitope mRNA vaccine candidate targeting three Ebola virus antigens — GP, NP and VP40 — for broad cellular immune recognition.
Malaria — PvRBP3 mRNA Vaccine Candidate
A multi-epitope mRNA design targeting PvRBP3, a key invasion protein of Plasmodium vivax, within a computational vaccinology framework.
HIV — Personalized mRNA Vaccine Design
An in-silico proof of concept for patient-specific HIV Env immunogens — personalized trimer design, codon-optimized mRNA and immune simulation.
Cordyceps-Like Fungal Pathogen — Hypothetical mRNA Vaccine
A hypothetical computational exercise: multi-epitope mRNA vaccine design for an imaginary Cordyceps-like fungal pathogen, for methods demonstration only.
Clostridial α-Toxin — mRNA-Based Hydrogel Therapeutic Concept
A stage-adaptive injectable hydrogel platform concept encoding a local α-toxin inhibitor with MgO nanoparticles for localized wound therapy design.
Dupuytren's Disease — TGF-β1 Protein Inhibitor Design
An AI-designed soluble TGF-β1 inhibitor (receptor-trap) concept with mRNA-based local expression for Dupuytren’s fibrotic disease research.
Scientific diagram available inside the case study
Acinetobacter baumannii — AI-Guided mRNA Vaccine Target Discovery
An AI-guided computational pipeline integrating CRISPR essentiality data and genomic analysis to rank mRNA vaccine targets against multidrug-resistant Acinetobacter baumannii.
SOD1-Linked ALS — AI-Assisted Variant Comparison
An open-source SOD1 sequence comparison exploring how a single amino-acid change (G94A) relates to plausible RNA-based therapeutic strategies for a genetic form of ALS — a research concept, not a proposed or demonstrated cure.
Scientific diagram available inside the case study
AI-Designed Synthetic Binding Protein Biosensor Platform
An AI-designed biosensor platform using synthetic binding proteins and colorimetric detection to identify and classify Gram-negative bacteria, Gram-positive bacteria, and fungal pathogens.
Scientific diagram available inside the case study
Lateral Flow IgE Immunoassay Apparatus
A rapid lateral-flow immunoassay concept for detecting and estimating allergen-specific IgE antibodies in a portable test format.
Scientific diagram available inside the case study
Five-Stage Magneto-Mechanical RF Energy Harvester
An energy-harvesting concept combining magneto-mechanical motion and RF energy capture for battery-free or emergency power applications.
Scientific diagram available inside the case study
Implant-Support & Osseointegration Technology
A granted U.S. patent covering implant-support technology designed to improve osseointegration, functional loading, and mechanical stability around implant systems.
These 16 research designs are portfolio examples only and are not for sale. No prices, shopping carts or purchase options are offered for this work. Research ownership and author attribution: Rami M. Alkhaleeli — Alkhaleeli BioAI LLC, along with any coauthors listed in the original documents.
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